Startups Valle del Cauca

The Cauca Valley has established itself as a hotbed of innovation, where talent, creativity, and entrepreneurial spirit converge to create solutions that address current and future challenges. From Cali, the epicenter of the technological and business ecosystem, to municipalities with a strong productive and cultural focus, startups are emerging that are redefining how we understand sustainability, health, education, industry, mobility, and much more.

This selection of startups represents the entrepreneurial spirit of a region that not only dreams of change, but builds it day by day. Each venture is born from a real and concrete need, but projects itself with a global vision, a bold approach, and a commitment to social, environmental, and economic impact.

Here you won’t just find names or logos. You’ll find stories of innovation, passionate teams, and proposals that are making a difference. This digital catalog is an open invitation to discover, connect, and collaborate with those leading the new economy from the Cauca Valley.

The startups we present here are the vibrant present and promising future of a region that is already generating transformation from its roots.

NANOSENUM

Nanosensum is a technology spin-off focused on developing advanced solutions for the agricultural sector. Its value proposition centers on precision phenotyping: the use of nanostructured sensors, artificial intelligence, and robotic platforms to detect, analyze, and manage plant stress early and efficiently.

This innovation allows farmers to anticipate diseases, nutritional deficiencies, and adverse conditions, thereby optimizing production processes and reducing losses. Nanosensum provides real-time data that facilitates strategic agronomic decision-making, improving yield, crop quality, and environmental sustainability.

Faced with the global challenge of producing more food for a constantly growing population, Nanosensum offers a concrete solution that positively impacts food security and the efficiency of natural resource use.

Source: Javeriana University Cali 

Contribution to the ecosystem:

Optimization of agricultural production based on technology.

Reducing the environmental impact of conventional agriculture.

Strengthening precision agriculture in Latin America.

Support for global food security.

MORPHITECH

Morphitech is a spin-off company that addresses a critical problem in the healthcare sector: medical errors resulting from insufficient or unrealistic training. To tackle this issue, Morphitech develops, manufactures, and markets high-precision, three-dimensional anatomical models specifically designed for medical and surgical simulation.

These models allow physicians, students, and healthcare professionals to train in a safe and realistic environment, significantly reducing risks during actual procedures. Thanks to its technology, Morphitech contributes to improving the quality of clinical training, patient safety, and the effectiveness of medical procedures.

The spin-off’s approach combines biomedical engineering, anatomical design, and clinical needs, with a strong applied research component. Morphitech aims to position itself as a leader in Latin America in the production of anatomical models and 3D organs for high-level medical and surgical training.

Source: Javeriana University Cali 

Contribution to the ecosystem:

Reduction of medical errors through improved training.

Realistic simulation with no risks to patients.

Integration of science, engineering, and medicine.

Support for educational institutions and health centers.

NPC Edugames

NPC Edugames is a spin-off company created to transform learning environments through the development of innovative educational games. Its approach combines fun, science, and pedagogy to address one of the major challenges in education today: student demotivation and the lack of effective methodologies that meet their real needs.

The company designs, develops, and markets analog, digital, and hybrid games, all based on scientific and pedagogical knowledge. These games are designed to strengthen academic and socio-emotional skills, aligning with the curricular objectives of educational institutions both nationally and internationally.

NPC Edugames aims to become a national leader in the development of high-impact educational gaming solutions. Its vision is centered on changing the way children and young people learn, making the process a comprehensive, fun, and motivating experience.

Source: Javeriana University Cali 

Contribution to the ecosystem:

Innovation in teaching and learning methodologies.

Strengthening student motivation.

Accessible, flexible, and scalable educational products.

Contribution to educational quality through play.

NATECO

It offers the market 100% biodegradable single-use products, made with biomaterials derived from waste, under a circular economy approach. Led by Professor Luz Marina Flórez of the Faculty of Engineering, it specializes in the production of products made with biomaterials, offering sustainable alternatives to replace polluting materials such as plastic.

The company focuses on utilizing agro-industrial waste to create biodegradable products. Among its featured products are biodegradable plates, bioplastics, and decorative candles made from waste oil. The initiative aims to address the growing demand for sustainable alternatives, contributing to the reduction of pollutants.

La empresa se enfoca en el aprovechamiento de residuos agroindustriales para crear productos biodegradables. Entre los productos destacados se encuentran platos biodegradables, bioplásticos y velas decorativas elaboradas a partir de residuos de aceite. La iniciativa busca abordar la creciente demanda de alternativas sostenibles, contribuyendo a la reducción de contaminantes.

Source: UAO

Learn more about the startups that are part of the Colombia Tech Report 2024

Learn more about the startups included in the DeepTech Report 2025

Andrés Méndez

Speaker principal

Conferencia “Innovación con impacto empresarial”

Presidente gremial, mentor y emprendedor serial

EdTech HUB LATAM + 90 Edtechs

Asociación de emprendedores +500 marcas de consumo

Ha logrado:

  • Diseñar estrategias de GTM en 14 países para diferentes proyectos.  
  • Crear, comprar y vender empresas. (Incluyendo grandes y dolorosos fracasos).
  • Ayudar en proyectos con múltiples corporaciones (Gobiernos, Scale ups, Startups, ONGs). 
  • Aprender de los mejores referentes; YCombinator, SOSV, Fuel de Mckinsey, entre otros. 
  • Ser mentoreado por banqueros, ejecutivos, y emprendedores seriales.  
  • Participar en el fondeo de Startups +$5M USD.
  • Actualmente se dedica a re-pensar, conectar y transformar industrias con problemas sistémicos en Colombia (Consumo) y Latino América (Educación con tecnología).

Xpanz en Valle 2023

Revive el evento aquí

El evento contó con la participación de más de 101 asistentes en la Universidad Javeriana Cali.

Fue el primer acercamiento entre IES aliadas y MiPyMEs beneficiarias.

17 de estas MiPyMEs presentaron su Pitch, 11 tecnologías de las IES aliadas fueron presentadas en el Experience Day, las cuales tuvieron 28 validaciones pre-comerciales.

Xpanz en Cauca 2024

Conferencista principal

Juan Cristóbal Constain

Conferencia: El camino de Quipu: de proyecto de investigación en MIT a fintech de inclusión financiera.

Cofundador y COO de Quipu Bank

Profesional en Gestión y Desarrollo Urbanos de la Universidad del Rosario, especialista en Derecho Urbano, y cuenta con una maestría en Planificación Urbana con énfasis en desarrollo económico del MIT. Como cofundador y COO de Quipu, una fintech de rápido crecimiento en Colombia, fue reconocido como Fellow del programa The Global Good Fund en 2023. Quipu ha recibido importantes reconocimientos de entidades como el Banco Mundial, Google, MIT, Forbes y Fast Company, consolidándose como un referente en inclusión financiera e innovación empresarial.

Xpanz en Valle 2024

Conferencista principal

Agustín Londoño

Director comercial de NotCo Colombia

Responsable de establecer la estrategia de negocio de NotCo en Colombia, en los frentes de Food Service, Retail. Administrador de negocios y especialista en mercadeo, con más de 25 años de experiencia liderando áreas de innovación en la industria de consumo masivo en Latinoamérica.

Xpanz en Cauca 2025

Conferencista principal

Claudia Aparicio

Conferencia: Efectos positivos de red.

CEO de Mentex y experta en innovación, reconocida entre los Top 100 gerentes de Colombia. Descubre cómo maximizar los efectos positivos de red y el impacto de la Alianza DeepTech en el fortalecimiento y escalamiento de startups en la región.